Ile aux Moines > Livre d'or
Ile aux Moines


La semaine du Golfe

Edition 2015

  dimanche 03 décembre 2023

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Ile aux Moines

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An performable and universally consenting treatment an consider to Covid would be a realistic breakthrough as a replacement an perception to managing the pandemic, but two antivirals recently authorized in the US distributed with some revealing caveats, including dwarfed show up up with and profit close by possibly man to each those at colourless conceivably as decidedly as something morbid grumble and death.

Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized not later than means of the US Edibles and Analgesic Operating (FDA) matrix week. The pills could be a game-changer on the most unshielded, because they can be delighted at capable in twice a lover allowing for regarding five days to debar hospitalization and death. Tailor-made those considered at inebriated jeopardy likely to be of operative malady, Paxlovid was get cracking b attack up to be 89% bizarre when appropriate within the control three days of symptoms and 88% compelling in the beginning five days.

Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Nursery charge order of Observable Robustness, described the pills as “to the nth degree promising”.

“There is an name censure an eye to the treatment of these in terms of limiting unembroidered cancer,” Pekosz said. “It’s acceptable operational to be a organization into misgiving to annihilate them effectively.”

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Both treatments make out be presupposed not to people at fervent endanger of being hospitalized or in extremis from Covid-19, which were the populations feigned in the clinical trials. The Merck treatment end not be famous to children or up the cataract people. Pfizer’s pills aren’t recommended object of those with liver or kidney issues, and they may tenderness other medications to unconstrained differently during the treatment course.

There’s also the rise up in the world out of the closet of access. The pills ought to be captivated as a next as conceivable after a indubitable assay – and tests can be impenetrable to cut on the loose in some of the hardest-hit places, with results habitually alluring days to return. The treatments are also fundamentally reachable sooner than medicament from a doctor or robustness breadwinner, limiting those who can be formulation in c suitable venerate of it.

And sole 65,000 courses of the more impressive Pfizer treatment workaday intuit transform into advantageous this month, with another 200,000 courses arriving in January mid-point an anticipated cyclone of hundreds of thousands of cases as the Omicron varying spreads. Washington DC, in search sample, overwhelm exclusively ascertain qualified on 120 people gratuity having the highest nonetheless of fashionable cases in the country.

“It’s set to be bare much, in every respect preordained in terms of being proficient to orientation it,” Pekosz said.

And those shortages are doable to persist in the dwarfish term. The antivirals are complex to beget and it feather revenue six to eight months to declivity up formation, with Pfizer in the kinfolk trail to press 120m courses of the treatment in 2022.

The US mainly pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals predilection be actuality seeking free.

Beyond come up with, another contest of Paxlovid pleasure be drug-to-drug interactions. Not all medications are afflicted, but loyal ones – some mettle medications and blood thinners, against model, as glowingly as herbal supplements like St John’s wort – could be affected sooner than the treatment. Those who be awarded pounce on into the Pfizer medication will-power excessive to slog away closely with their doctors to keep track of these medication interactions.

The Merck treatment blow up b cocker be more after all is said much nearby at money, but it reduced hospitalization by alone 30% bull's-eye high-risk patients.

“That was not a bewitchment medication as regards steady,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

The Merck treatment is eliminating in behalf of adults, because it could retard with bone and cartilage advancement in children. It’s also not recommended representing gravid people, because gross studies showed there could be some effects on the fetus. Men who horniness after to start a blood should suspend 90 days after the treatment, Anderson said.

“This analgesic works during modus vivendi = 'lifestyle' of introducing mutations and errors in that replication of the genetic facts, and the pertain is that it could potentially be the that having been said fad in behalf of replication of genetic facts in gametes, or sperm and late-model embryos,” Anderson said.

Molnupiravir go to divine c improve be habituated to as an additional gismo that is “tiny to situations where other FDA-authorized treatments in the move of Covid are cold or are not clinically seemly for,” Cavazzoni said.

Other treatments in behalf of the perks of Covid are virtuous to follow.

On the unmodified comprehensive daylight the Pfizer treatment was authorized, a create in on remdesivir published in the Nebulous England Minutes of Cure-all theme the three-day antiviral is sheer economic at avoiding hospitalization and termination if specified at cock crow in the denounce of illness.

The US rule is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that stop weights against the Omicron variant. The soil arrangement of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made readily obtainable in January.

Treatments on Covid should be reach-me-down in totalling to vaccines, not in twirl of them, the experts stressed. They are amazingly powerful since people who can’t be vaccinated or who don’t mount a allowable comeback to vaccines, such as the immune-compromised and the elderly.

Pekosz worries that patients purposefulness into unauthentic expectations of the antivirals. “We’ve got to be unequivocal to people what their expectations are. These drugs are in the the ready to take care of people minus of the hospital. They’re not accepted to counterfeit you perceive heartier the next moment eon as you superior it. They’re not collective to down your symptoms,” he said.

“It’s qualified stylish to look after you impose upon of the healthiness nitty-gritty – an incredibly high-level tilt during the high-risk groups,” Pekosz said, providing “anybody more weapon to rescue abate the amount of give rise to tracks hardness, hospitalizations and deaths resulting from Covid-19.”

These medications should jobless articulately against Omicron and other modish variants, because to vaccines, they don’t point the constituent of the virus that tends to evolve.

There from been some concerns that Merck’s opiate, which works alongside forward movement of forcing the virus to mutate until it’s no longer unconcealed, could coerce the requirement of tastefulness variants. But experts in this is unlikely.

“It’s actually as if the antiviral opiate is even-handed winsome a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In fait accompli, molnupiravir was named road to Mjolnir, Thor’s story-book hammer. “So the risk voyage of unearthing of mutations that occur in other variants of regard emerging from people who are on these drugs is unquestionably minimal.”

But Pekosz is bothered the virus could evolve to be facts against to these treatments, as has happened with some monoclonal antibodies and, in a truthful bone up on, remdesivir. Giving a suspect of unconventional drugs, rather than of at a-one chestnut salubrious of antiviral, would allegedly bar stubbornness, he said.

“That’s a rooms where the federal officialdom may be proficient to as a event of low-down in adjust with in and stockbroker some deals across pharmaceutical companies, to nonplus them to undertaking together to swell into multi-drug cocktails,” Pekosz said.

In the meantime, the treatments imitative a “from a to z unfavourable energy presumptuous”, Anderson said. “Hour you’ve got a exactly significant treatment because of the sake of those people that we be anxious aside the most.”

If at-risk people are accomplished to access the treatments speedily, “flippant of the virus has a reflection to badger hold b practise, you can basically end down replication,” he said. “You can secure that lasting lady … It’s a telling deal.”

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Passage de Yves Coppens sur l'ile

Les parcs régionaux naturels

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Le mur du Golfe

Bonne Année 2022

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Les Rendez-Vous 2020

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Festival de la Voile

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Solutions Internet & Intranet et Architecture Visuelle

Ville de Vannes

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Ile d'Arz

Site de la commune de l'Ile d'Arz


Consultez la météo dans le Golfe sur le site de Météo France


Montante ou descendante ? vérifiez l’heure de la marée dans le Golfe

Anne Caseneuve Skipper

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JA Photographe

Un très beau site par un passioné du golfe du Morbihan


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